Calcium antagonists and the heart.

[Calcium antagonists in the treatment of ischemic heart disease].

Using clinical and instrumental findings, the therapeutic effectiveness, hemodynamic effects and tolerance of the three nifedipin derivatives adalate (FRG), corinfar (GDR) and fenigidin (USSR) were studied in 51 patients. The data provided by questioning, examinations and bicycle ergometric tests showed an antianginal effect in 68.5% of the patients treated with corinfar and adalate, and in 61%...

Atherosclerosis, calcium, and calcium antagonists.

Why are calcium antagonists still being used in heart failure in the era of calcium sensitizers?

Efficient treatment for dilated cardiomyopathy has become a challenge to research in heart failure. The high morbidity and mortality ratios with their consequent social impact, justify high levels of anxiety. In Brazil, 2 million patients have heart failure, and 240 thousand new cases appear every year. Approximately one third of these patients are hospitalized due to failure of compensation of...

Clinical pharmacology of calcium antagonists. Satellite symposium on calcium antagonists.

A new class of agents has been made available for the treatment of hypertension. These calcium antagonists have rapid bioavailability and dramatic antihypertensive effects through reduction of total peripheral resistance and the vascular resistance of the major target organs of the body. These changes are usually associated with unchanged cardiac output, preserved organ blood flows, maintained ...

Calcium antagonists and endothelial function